Motor neuron disease clinical performance

Slow onset, the course can also be a sub-acute symptoms according to the damaged site. As motor neuron disease of the spinal cord front-selective cells in the brain cranial nerve movement of nuclear movement brain cortex and pyramidal cells, pyramidal tract, so if the disease-oriented motor neurons, called the conduct of spinal muscular atrophy Disease; disease if over-oriented motor neuron, called primary lateral sclerosis cable; if, the lower-level motor neuron damage there at the same time, known as amyotrophic lateral sclerosis; if medullary motor neuron disease to the degeneration Lord, then known as the medullary sexual paralysis. Clinical for sexual spinal muscular atrophy, amyotrophic lateral sclerosis most common.
  the disease is mainly manifested, the first symptoms more common in some hands, with fingers sense of movement weakness, rigid and clumsy, hand muscles gradually shrinking, that muscle bundle tremor. Remote limbs were carried out muscular atrophy, about half of cases over the side of the early upper hand with the size of fish muscle atrophy, later extended to the forearm muscles, and even pectoralis major, back muscles can atrophy, small leg muscles can atrophy, muscle Shrinking physical weakness, muscle tension (the sense of traction), the muscle bundle fibrillation, action difficulties, dysphagia and respiratory symptoms. As of early lesions of bilateral pyramidal tract, there will be two-leg first spastic paraplegia.