According to clinical symptoms and signs, EMG, biochemistry and muscle biopsy, family history, genetic diagnosis if it is not difficult to establish, subject to the following diseases and identification:
1. Infant with spinal muscular atrophy and DMD is the main difference between the age of onset is earlier, sometimes visible muscle bundle tremor, muscle atrophy in the limbs remote also clear that EMG and muscle biopsy for identification.
2. Dystonia benign congenital disease or infants with congenital muscular dystrophy identification period, characterized by non-muscular atrophy, CPK in normal, non-specific muscle biopsy revealed that the prognosis is good.
3. Adults with spinal muscular atrophy and the major limb-girdle muscular dystrophy distinction, according to the serum-determination, EMG and muscle biopsy, and whether muscle bundle tremor, the general can be identified. For difficulties, can be Coers (1979) in the muscle biopsy at the end of innervation ratio (terminal innervation ratio, TIR) approach to estimate muscle movement in the process of axonal side of the branch (that is, a certain number Asia Axonal terminals dominated by the number of muscle fibers), such as TIR can be increased for the diagnosis of spinal muscular atrophy, should be considered normal for myopathy.
4. Polymyositis main difference with limb-girdle, myositis developed quickly, often muscle-ache, and there is no family history of genetic, muscle biopsy often can be clearly identified.
5. Amyotrophic lateral sclerosis cable with a remote muscular dystrophy distinction, in addition to clinical muscular atrophy, there are muscle tension, tendon hyperreflexia and pathological reflection, and often have muscle bundle tremor.
6. Myasthenia gravis have to eye with ocular and pharyngeal muscle-type distinction, myasthenia gravis have easy fatigue and fluctuations in the characteristics of the new Andean prescribed or Tensilon test marked improvement, EMG can also be identified.
7. Myotonic muscular dystrophy has muscle stiffness, accompanied cataracts, hair loss and gonadal atrophy, little change in serum enzyme.
1. Infant with spinal muscular atrophy and DMD is the main difference between the age of onset is earlier, sometimes visible muscle bundle tremor, muscle atrophy in the limbs remote also clear that EMG and muscle biopsy for identification.
2. Dystonia benign congenital disease or infants with congenital muscular dystrophy identification period, characterized by non-muscular atrophy, CPK in normal, non-specific muscle biopsy revealed that the prognosis is good.
3. Adults with spinal muscular atrophy and the major limb-girdle muscular dystrophy distinction, according to the serum-determination, EMG and muscle biopsy, and whether muscle bundle tremor, the general can be identified. For difficulties, can be Coers (1979) in the muscle biopsy at the end of innervation ratio (terminal innervation ratio, TIR) approach to estimate muscle movement in the process of axonal side of the branch (that is, a certain number Asia Axonal terminals dominated by the number of muscle fibers), such as TIR can be increased for the diagnosis of spinal muscular atrophy, should be considered normal for myopathy.
4. Polymyositis main difference with limb-girdle, myositis developed quickly, often muscle-ache, and there is no family history of genetic, muscle biopsy often can be clearly identified.
5. Amyotrophic lateral sclerosis cable with a remote muscular dystrophy distinction, in addition to clinical muscular atrophy, there are muscle tension, tendon hyperreflexia and pathological reflection, and often have muscle bundle tremor.
6. Myasthenia gravis have to eye with ocular and pharyngeal muscle-type distinction, myasthenia gravis have easy fatigue and fluctuations in the characteristics of the new Andean prescribed or Tensilon test marked improvement, EMG can also be identified.
7. Myotonic muscular dystrophy has muscle stiffness, accompanied cataracts, hair loss and gonadal atrophy, little change in serum enzyme.
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