Scientists have been targeted mu-crystallin protein in excess of a shoulder-brachial progressive muscular dystrophy pathogenic molecular mechanism of the new hypothesis. But researchers said this new type of shoulder brachial to the hypothesis of muscular dystrophy, is not to deny the existing shoulder-to-brachial the hypothesis of muscular dystrophy.
American Association of neuromuscular disease in the United States funded the University of Maryland School of Medicine Robert Bloch and his colleagues found that brachial-to-shoulder of muscular dystrophy in the muscles of patients with samples of the mu-crystallin protein level no higher than the neuromuscular disease, other Neuromuscular disease patients and patients suffering from muscle inflammation.
The researchers have their research report published in July 2007 published in the "Experimental Neurology" magazine, in their view, shoulder-to-brachial muscular dystrophy patients, other non-muscle tissue of the disease can be interpreted as shoulder - Brachial-progressive muscular dystrophy patients with other organizations in the mu-crystallin protein level changes. Shoulder-to-brachial muscular dystrophy patients often do not normally associated with the retina, probably because of the retina of the mu-crystallin protein in the abnormal, mu-crystallin protein in normal also impossible not cause deafness, some Shoulder-to-brachial muscular dystrophy patients with significant decline in the hearing.
In addition mu-crystallin protein interaction with a thyroid hormone, thyroid hormone is in the early mature muscle cells play an important role in the signaling molecule. Mu-crystallin protein synthesis of the gene in the human chromosome 16, but now researchers known brachial-to-shoulder muscular dystrophy gene defect on the 4th of human chromosome deletion of a section of DNA, has for a long time On the 4th suspected human gene on chromosome deletion would affect the chromosome from which the gene, including the other chromosome. Since the publication of the above studies, the study's main author, University of Maryland School of Medicine in the United States Patrick Reed was the United States Association of neuromuscular disease research funding brachial-shoulder type of muscular dystrophy to the mu-crystallin protein and other protein Not normal.
American Association of neuromuscular disease in the United States funded the University of Maryland School of Medicine Robert Bloch and his colleagues found that brachial-to-shoulder of muscular dystrophy in the muscles of patients with samples of the mu-crystallin protein level no higher than the neuromuscular disease, other Neuromuscular disease patients and patients suffering from muscle inflammation.
The researchers have their research report published in July 2007 published in the "Experimental Neurology" magazine, in their view, shoulder-to-brachial muscular dystrophy patients, other non-muscle tissue of the disease can be interpreted as shoulder - Brachial-progressive muscular dystrophy patients with other organizations in the mu-crystallin protein level changes. Shoulder-to-brachial muscular dystrophy patients often do not normally associated with the retina, probably because of the retina of the mu-crystallin protein in the abnormal, mu-crystallin protein in normal also impossible not cause deafness, some Shoulder-to-brachial muscular dystrophy patients with significant decline in the hearing.
In addition mu-crystallin protein interaction with a thyroid hormone, thyroid hormone is in the early mature muscle cells play an important role in the signaling molecule. Mu-crystallin protein synthesis of the gene in the human chromosome 16, but now researchers known brachial-to-shoulder muscular dystrophy gene defect on the 4th of human chromosome deletion of a section of DNA, has for a long time On the 4th suspected human gene on chromosome deletion would affect the chromosome from which the gene, including the other chromosome. Since the publication of the above studies, the study's main author, University of Maryland School of Medicine in the United States Patrick Reed was the United States Association of neuromuscular disease research funding brachial-shoulder type of muscular dystrophy to the mu-crystallin protein and other protein Not normal.
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